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Systems Neuroscience

Laboratory of Cognitive and Behavioral Neuroscience

Susumu Takahashi, Ph.D.
It is generally accepted that the functioning of cognition and behavior such as listening, touching, moving, memorizing and remembering is realized by transmitting neuronal activity in the brain – a sophisticated and complex network consisting of several billions of neurons. However, the fundamental principle remains unclear. The aim of our laboratory is to unravel how the brain realizes the cognition and behavior. Since we believe that a multi-faceted approach is a prerequisite for realizing our aim, we employ five multidisciplinary methodologies: 1) large-scale multi-unit recording across the hippocampal formation, cortex and basal ganglia of freely behaving mice and rats, 2) optogenetics with transgenic animals, 3) behavior analysis based on operant conditioning, 4) statistical analyses for neuronal recordings based on machine learning, 5) automatic recording/stimulation devices based on real-time processing.
For instance, we preferentially focus on place cells, i.e., hippocampal pyramidal cells maximally firing at a specific location. To decipher the encoding and retrieval of episodic memory of what happened at a specific place and time, we decode experienced episodic-like memory from the hippocampal place cell activity sequences. Moreover, we attempt to manipulate those memories by selectively controlling the place cell activities. On the other hand, wild animals such as seabirds sometimes traverse several hundred kilometers long journeys without landmarks. We examine the neuronal mechanisms underlying such an astounding navigation ability by comparing the place cell activity among species.
Ken-ichi Mizutani, Ph.D.

Research topics

  1. Neural substrates of episodic memory encoding and retrieval
  2. Neuronal mechanisms underlying spatial navigation

Selected publications

  1. Takahashi, S., Episodic-like memory trace in awake replay of hippocampal place-cell activity sequences, eLife, 4:e08105, 2015.
  2. Takahashi, S., Hierarchical organization of context in the hippocampal episodic code, eLife, 2:e00321, 2013.
  3. Terada S., Takahashi S., and Sakurai Y., Oscillatory interaction between amygdala and hippocampus coordinates behavioral modulation based on reward expectation, Frontiers in Behavioral Neuroscience. 7(177), 1:12, 2013.
  4. Sakurai, Y., and Takahashi, S., Conditioned enhancement of firing rates and synchrony of hippocampal neurons and firing rates of motor cortical neurons in rats, European Journal of Neuroscience, doi:10.1111/ejn.12070, 1-17, 2012.
  5. Takahashi, S., and Sakurai, Y. Information in small neuronal ensemble activity in the hippocampal CA1 during delayed non-matching to sample performance in rats, BMC Neuroscience, 10:115, 2009.
  6. Takahashi, S., and Sakurai, Y. Sub-millisecond firing synchrony of closely neighboring pyramidal neurons in hippocampal CA1 of rats during delayed non-matching to sample task, Frontiers in Neural Circuits, 3:9, 2009.
  7. Takahashi, S., and Sakurai, Y. Coding of spatial information by soma and dendrite of pyramidal cells in the hippocampal CA1 of behaving rats, European Journal of Neuroscience, 26(7), 2033-2045, 2007.
  8. Sakurai, Y., and Takahashi, S., Dynamic synchrony of firing in the monkey prefrontal cortex during working memory tasks, Journal of Neuroscience, 26, 10141-10153, 2006.
  9. Takahashi, S., and Sakurai, Y. Real-time and automatic sorting of multi-neuronal activity for sub-millisecond neuronal interactions in vivo. Neuroscience, 134, 301-315, 2005.
  10. Takahashi, S., Anzai, Y. and Sakurai, Y. Automatic sorting for multi-neuronal activity recorded with tetrodes in the presence of overlapping spikes, Journal of Neurophysiology, 89, 2245-2258, 2003.


Susumu Takahashi, Ph.D. (Principal investigator, Professor)
Kaoru Ide, Ph.D. (Research assistant professor)
Akira Masuda, Ph.D. (Research assistant professor)


Takahashi Lab


1-3 Tatara Miyakodani, Kyotanabe-shi, Kyoto 610-0394 Japan
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